- Activate anti-aging mechanisms*
- Enhance energy metabolism*
- Protect against oxidative stress*
With the help of some of the world’s leading scientific researchers, we are committed to delivering you the latest discoveries and expert discussions that surround NR.
Our goal is to inform and empower you with useful information about NR as you consider your own health-longevity.
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats
Published in: Journal of the International Association for the Study of Pain (PAIN) Injury to sensory afferent nerves may contribute to the peripheral neuropathies that develop after administration of chemotherapeutic agents. Manipulations that increase levels of nicotinamide adenine dinucleotide (NAD+) can protect against neuronal injury. This study examined whether nicotinamide riboside (NR), a next-generation form
Written by: Amy Boileau, Ph.D., R.D. In a paper published in the journal PNAS, researchers at Washington University School of Medicine in St. Louis reported that glioblastoma tumors over-produce NAMPT, an enzyme which is involved in the creation of NAD+. The researchers used animal and cell models to demonstrate that if the activity of this
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Published in PNAS. Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD+). Nevertheless, how the regulation of this metabolic cofactor interfaces with signal transduction networks remains poorly understood in glioblastoma. Here, we report nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting step in NAD+ synthesis, is highly expressed in glioblastoma
Published in PLOS One. We need NAD+ in our cells to make an enzyme called PARP, which fights oxidative damage and helps keep our DNA in good repair. We also need NAD+ to support the activities of enzymes called sirtuins, the so-called “longevity enzymes”. It’s been established in rodents that there are links between age-related
NAD+ Replenishment Improves Lifespan & Healthspan in Ataxia Telangiectasia Models Models via Mitophagy and DNA Repair
Published in Cell. Ataxia telangiectasia (A-T) is a rare disease involving a recessive chromosome. It is characterized by progressive deterioration of the nervous system, and the inability to hold the head, arms and legs in proper position. A-T is caused by defects in an enzyme called ATM, which regulates the body’s ability to repair its
Published in Nature Communications. NAD+ plays a vital role in many of the body’s cellular processes. To supply cells with NAD+, the body converts NR into a compound called NMN which then gets converted to NAD+. Supplementing with NMN or NR protects against age-related diseases, degenerative diseases of the nervous system and metabolic diseases. In
Published in Nature Communications. Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD+ metabolism in humans. We report that human blood NAD+ can rise as much as 2.7-fold with a single oral dose of NR in a pilot study
Published in Cell Metabolism. Our cells need NAD to fuel our metabolism. However, aging and exposure to environmental stresses can deplete the amount of NAD in our tissues. In this study, researchers were working to establish how low these levels of NAD can go before tissues start to malfunction. They first eliminated an enzyme in