Decline in NAD+ Level with Age
Graph based on data from Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue. PLoS ONE, 7(7). doi:10.1371/journal.pone.0042357
NAD+ is a molecule found in every cell in the body that is used to power metabolism, construct new cellular components1, resist free radical and DNA damage and send signals within the cells.2,3 It enables the mitochondria – the ‘powerhouses of the cell’ to convert the food we eat into the energy our body needs to sustain all its functions. It is also required to “turn off” genes implicated in accelerating aging processes.4,5
Healthy mitochondrial function, is an important component of healthy human aging. Our body naturally has the ability to make NAD+ from components in the food we eat. Research in laboratory animals and people shows that as we age, levels of NAD+ declines substantially. This decline leaves us at greater risk for neuro and muscular degeneration6, declines in our cardiometabolic health7 and our capacity for repair and resiliency.
Research suggests NAD+ is key to increasing the amount of time we spend in good health.4-7
Scientists at prestigious research institutions have been investigating NAD+ boosting strategies as a therapy for degenerative conditions related to aging. Research indicates that NAD+ plays a unique role in muscle and tissue protection, as well as increasing lifespan.4,8