How does NR work?

How Does NR (Nicotinamide Riboside) Help Boost Cellular Energy?
NAD+Nicotinamide Adenine Dinucleotide  is the key that enables the mitochondria – the “power station” within the cell, to undergo cellular energy production.

NR has been proven to boost NAD+ levels in humans.1  


  You Need Cellular Energy

The body has many different needs and demands to keep itself active and functioning properly. Cellular energy is what powers all of the body’s functions such as keeping the heart beating, the lungs expanding and contracting, and enabling the brain to process thought.

Cellular energy not only fuels our most basic bodily functions, it also is necessary to defend against oxidative stress in the body, repair DNA damage, create the building blocks for DNA and RNA , and to “turn on” ‘longevity promoting’ proteins called sirtuins.9

NR is the Most Effective B3 at Boosting NAD+ and Activating Longevity Promoters1

It is true all forms of vitamin B3 have the ability to boost NAD+ in the body to some degree. However, the way each unique molecule is metabolized in the body can have a significant impact on each molecule’s ability to boost NAD+ and promote longevity. Dose-related side effects, such as flushing commonly associated with niacin, can also limit an individual’s ability (and desire) to further increase their consumption in pursuit of additional boosts in NAD+.

A recently published pre-clinical study demonstrated that when tested head-to-head-to-head (NANiacin/Nicotinic Acid vs. NamNicotinamide vs. NRNicotinamide Riboside), NR was not only the most effective NAD+ booster, but it was also the most effective at turning on of the longevity-promoting proteins called sirtuins.

NR is the Most Efficient B3 at Boosting NAD+1
When it comes to cellular energy in the body, our desire is to MAXIMIZE IT! Converting the B3s into the molecules which eventually become NAD+ expends some of our precious cellular energy – and some forms of B3 such as nicotinamide expend more energy than the others while undergoing this process.

Think of this process like an assembly or production line. We start with an input. That input is touched and changed in various ways along the assembly line and those changes result in a finished product or output.

With respect to NAD+ production, the inputs are the particular form of B3 and the finished products are NAD+ (which will go on to enable to body to produce cellular energy). Within the body, the process to convert each form of B3 into NAD+ varies in length and complexity. The processes to convert niacin and nicotinamide to the finished product are more energy intensive to the body than is the process for NR.

Pre-clinical research has demonstrated that supplementing with NR not only safely boosts NAD+, but it also enhances the body’s utilization of NAD+ to a greater degree than all other forms of vitamin B3. This means the more NR boosts NAD+, the more the body uses to maximize cellular energy production. That’s why NR is considered the most efficient and effective NAD+ booster available, when administered orally.1

Cellular Energy is Different than Stimulant Based Energy
Cellular energy is a different type of energy than the caffeine driven energy boosts one can experience after drinking coffee or energy drinks. Though in high demand, this type of wired, rapid response energy promoters also can result in rapid consequences such as anxiousness or jitteriness, increased heart rate and blood pressure, blood sugar spikes and an energy crash later in the day.2

Cellular energy production, in contrast, is happening within your body every day. When adequate levels are achieved, a person may simply feel like they have a general sense of well-being and enough healthy vigor to take on the day.

Similar to taking a multi-vitamin, NR is unlikely to cause immediate, noticeable effects. NR is not a stimulant, nor does it cause the uncomfortable ‘hot flash like’ side effect of flushing often experienced when taking niacin. When taking NR, one may subtly notice any or all of the following effects:

  • Improved cognitive function3
  • Improved endurance due to enhanced mitochondrial function3
  • Improvements in occasional sleep disturbance3
What are the benefits of NR?



  1. Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Abel, E.D., Migaud, M.E., Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948. doi:10.1038/ncomms12948
  2. Johns Hopkins University School of Medicine. (n.d.). Behavioral Pharmacology Research Unit (BPRU) Fact Sheet – Caffeine Dependence. Retrieved August, 2016, from
  3. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.