Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Published in Cell.

When the mitochondria in our cells start to decline, it’s called mitochondrial dysfunction. This dysfunction is considered a hallmark of aging but what causes it is under debate. These researchers found that during aging, the communication (metabolic pathway) between the cell’s mitochondria and its nucleus is disrupted. The disruption was traced to a decline in the amount of NAD+ in the cell’s nucleus.

Researchers found that raising NAD+ levels in aging mice restores mitochondrial function to that of young mice. They concluded that reducing the enzymes responsible for good communication between the nucleus and the mitochondria contributes to declining mitochondria function with age, a process that is apparently reversible.

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